par Appelboom, Thierry 
;Famaey, Jean Pierre ;Wybran, Joseph ;Govaerts, André
Référence European journal of rheumatology and inflammation, 1, 3, page (242-248)
Publication Publié, 1978
;Famaey, Jean Pierre ;Wybran, Joseph ;Govaerts, André Référence European journal of rheumatology and inflammation, 1, 3, page (242-248)
Publication Publié, 1978
Article révisé par les pairs
| Résumé : | The effects of some non-steroidal anti-inflammatory drugs (NSAID) on the Two-stage Leucocyte Adherence Inhibition Test was studied at three different levels: adherence of normal leucocytes to glass, binding of cytophilic IgG to leucocytes (sensitization) and recognition of antigen by sensitized leucocytes. For that purpose, 106 normal circulating leucocytes were preincubated with serum or IgG from polyarthric patients and tested for their specific response to an antigenic synovial extract. Various concentrations of NSAID (indomethacin, flufenamic acid, phenylbutazone) were added to normal leucocytes in the absence of serum and before or after sensitization with polyarthritic serum. The reactivity of the cells was tested against a synovial extract. The results showed that NSAID at concentrations ranging from 10-6 to 10-10M could inhibit the sensitization whereas no effect was demonstrated on the leucocyte glass adherence or on the antigenic recognition. This inhibition was completely reversed by prostaglandin E2. These observations which suggest a possible role for prostaglandins in the binding of cytophilic IgG on leucocytes in vitro could be of some interest for the understanding of the mode of action of NSAID in the treatment of rheumatic diseases. |
