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Ventilation and blood gases dissociation during almitrine infusion in chronic and acute stages of chronic obstructive lung disease

par Sergysels, Roger ;Naeije, Robert ;Mols, Pierre
Référence Revue Francaise des Maladies Respiratoires, 8, Symp., page (155-163)
Publication Publié, 1980

Article révisé par les pairs

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Résumé :

Almitrine was given intravenously (0.25; 0.50; 1 mg/Kg/30 min) to 33 patients affected by COLD at a chronic stage or during acute decompensation. All subjects except two had hypoxia and most of them were CO2 retainers. The benefits at 15 minutes of almitrine perfusion were the following : an increased respiratory drive for breathing with a slight but significant increase in ventilation and respiratory frequency; highly significant changes in PaO2 and PaCO2 (respectively + 7.40 and - 3.9 mmHg); a decreased alveolar to arterial gradient for O2. These changes were accompanied by a significant increase in pulmonary pressure and in some patients by dyspnea and ill-feeling. The blood gas changes could not be related to hyperventilation only and it is suggested that almitrine may reduce the ventilation perfusion inequalities in the lung.