par Yernault, Jean Claude ;Van Muylem, Alain ;Noseda, André
Référence European journal of respiratory diseases, 62, SUPPL. 126, page (265-270)
Publication Publié, 1983
Article révisé par les pairs
Résumé : Despite the lack of effect on the lung mechanics and ventilation distribution, a definite improvement in gas exchange was observed after almitrine bismesylate without any change in the minute ventilation and pattern of breathing. Moreover, neither the increases in PaO2 nor the decrease in PaCO2 could be related to the changes in the alveolar ventilation, confirming that the improvement in the V̇a/Q̇ ratios distribution is a very important mode of action of almitrine bismesylate besides its direct effects on the peripheral chemoreceptors observed mainly when higher dosages than in the present study are used.

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