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Demonstration of two bactericidal thresholds of cefpirome (HR-810) activity of Escherichia coli by kinetic turbidometry and killing curves

par Yourassowsky, Eugène ;Van der Linden, Martial;Lismont, M.J.
Référence Current therapeutic research, 40, 5, page (825-829)
Publication Publié, 1986

Article révisé par les pairs

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Résumé :

The antimicrobial activity of cefpirome on a culture of Escherichia coli was measured by kinetic turbidometry and killing curves. At lower concentrations (0.06 μg/ml to 1 μg/ml), the killing rate was independent of drug concentration. At the higher concentrations (4 μg/ml to 256 μg/ml), the bactericidal activity depended on drug-concentration. The measurement of the early increase in optical density was predictive of the two thresholds of bactericidal activity.