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Paradoxical action of penicillin G on Staphylococcus aureus: a time study of the effect of a zonal antibiotic concentration gradient on bacterial growth

par Yourassowsky, Eugène ;Vanderlinden, M P;Lismont, M.J.;Schoutens, ELISABETH
Référence ANTIMICROB.AGENTS CHEMOTHER., 8, 3, page (262-265)
Publication Publié, 1975

Article révisé par les pairs

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Résumé :

The killing rate of a zonal concentration gradient of penicillin G on S. aureus was studied by using a previously described triple layer technique, enzymatic inactivation of the antibiotic, and an automatic image analyzer. This gradient determines a target image, whose center is the reservoir of antibiotic (constituted by a paper disk containing 100 U of penicillin G) and whose successive concentric zones are: a zone of slow bactericidal activity (corresponding to high levels of penicillin G), a zone of maximal bactericidal activity (corresponding to optimal levels of penicillin G), and a zone of overgrowth situated in front of the antibiotic wave.