par Schoutens, ELISABETH;Vanderlinden, M P;Yourassowsky, Eugène 
Référence Acta clinica Belgica (Ed. multilingue), 27, 5-6, page (578-584)
Publication Publié, 1972
Référence Acta clinica Belgica (Ed. multilingue), 27, 5-6, page (578-584)
Publication Publié, 1972
Article révisé par les pairs
| Résumé : | Tobramycin was administered in a dosage of 3-5 mg/kg/daily to 30 hospitalized adult patients. In 21 of the 24 patients suffering from urinary tract infections, elimination of the causative microorganisms was obtained within 48 hours, and in 8 of these cases no relapse occurred after the treatment was stopped. In the other six patients with diverse infections (pulmonary, biliary, cutaneous), the clinical and bacteriologic results were incomplete. The average urinary concentration of tobramycin was 216 g/ml. The antibacterial activity of the majority of the samples was excellent, thus corroborating the clinical effect observed. The average serum concentration was between 5 and 10 μg/ml one hour after an intramuscular dose and between 2 and 3.5 μg/ml 8 hours after it. These levels, which are close to the generally measured M.I.C., could confer only a weak antibacterial activity on the samples studied, thus accounting for the partial clinical results obtained. |
