par Ledoux, Marguerite 
;Achten, Georges
Référence Journal of cutaneous pathology, 2, 1, page (25-29)
Publication Publié, 1975-02
;Achten, Georges Référence Journal of cutaneous pathology, 2, 1, page (25-29)
Publication Publié, 1975-02
Article révisé par les pairs
| Résumé : | A 19-year-old Moroccan male was found to have total absence of serum alpha1-antitrypsin, a major inhibitor of elastase. This patient had chronic obstructive lung disease, hyperextensibility of the skin over the cheeks and wrists, and hyperlaxity of the hand joints. Microscopic sections of the skin revealed a thickened dermis with shortened and rarefied clastic fibers. Ultrastructural study showed collagen fibers with variable and irregular diameters. Elastic fibers were scarce and their relatively poor matrix was surrounded by numerous microfibrils. The outline of the fibers was irregular with deep recesses filled with microfibrils. The ergastoplasm of the fibroblasts was well developed. The differential diagnosis with other connective dystrophies showed the original characteristic of this case. Clinically and histopathologically, the skin abnormalities are probably related to the deficiency in elastase inhibitor. |
