par Wolter, Renee Adrienne 
;Noel, Pierre Raoul ;De Cock, Paul
Référence Acta paediatrica Scandinavica, 68, Suppl. 277, page (41-46)
Publication Publié, 1979
;Noel, Pierre Raoul ;De Cock, PaulRéférence Acta paediatrica Scandinavica, 68, Suppl. 277, page (41-46)
Publication Publié, 1979
Article révisé par les pairs
| Résumé : | Neuropsychological assessment was carried out in 57 patients aged 3.0 to 17.5 yr (mean 8.5) with thyroid dysgenesis under adequate long-term therapy. Starting age of hypothyroidism as estimated by bone age at diagnosis was prenatal in 32 cases, close to birth in 13 cases and postnatal of 1-12 months in 12 cases. Hypothyroidism of prenatal onset results in severe neuropsychological disorders and mental retardation if not treated early. Only some signs of 'minimal brain dysfunction', which compensate with advancing age and normal IQ, are found in these children if therapy is started before one month of age. Hypothyroidism starting at birth does not result in mental retardation, but neuropsychological disorders are found. They are more frequent if treatment is started after 6 mth of age. Children who become hypothyroid between 1 and 12 mth of age are usually not mentally retarded and show minor neuropsychological disorders. |
