par Viré, Jean-Claude ;Patriarche, Gaston ;De Jager, Robert ;Dupont, Daniel;Christian, Gary D.
Référence Fresenius' Zeitschrift für Analytische Chemie, 307, 4, page (277-282)
Publication Publié, 1981-01
Référence Fresenius' Zeitschrift für Analytische Chemie, 307, 4, page (277-282)
Publication Publié, 1981-01
Article révisé par les pairs
Résumé : | The electrochemical characteristics of 2-formylpyridine thiosemicarbazone (2-FPTS) have been studied by direct current, alternating current, and differential pulse polarography and cyclic voltammetry at a mercury electrode. This new cytostatic agent is reduced in a two-electron irreversible step at the nitrogen double bond of the side chain, in the pH range 0.2-12. A double anodic wave very close to the oxidation wave of mercury, corresponding to the formation of an organo-mercury compound, develops in neutral and alkaline media. These different electrochemical reactions are complicated by adsorption. In alkaline media, the carbon-nitrogen double bond reduction current decreases progressively with increasing pH due to formation of an electrochemically inactive species. Finally, a catalytic reduction wave of protons is developed in neutral solutions. Quantitative determination of the compound was possible in the range 1×10-7 to 1×10-3 M, using the diffusion controlled reduction wave at pH 7. The qualitative detection limit is 2×10-8 M (4 ng/ml). © 1981 Springer-Verlag. |