par Regnier, René 
Référence Revue médicale de Bruxelles, 13, 5, page (172-176)
Publication Publié, 1992-05
Référence Revue médicale de Bruxelles, 13, 5, page (172-176)
Publication Publié, 1992-05
Article révisé par les pairs
| Résumé : | Total body irradiation produces a sufficient immunosuppression to prevent an allograft rejection. It can be used with chemotherapy as an "intensive" treatment aiming at the complete eradication of a malignancy--with the resulting bone marrow aplasia needing an autologous or allogeneic transplantation. In either case, a dose of some 10 Gy has to be delivered in the whole body, in one session at low dose rate or fractionated between several sessions. Such a dose is usually well tolerated--at any rate it does not carry too high a risk to contribute to induce an interstitial pneumonitis or a venous occlusive disease of the liver. The antitumoral efficacy of such limited dose is mainly important against very radiosensitive tumours--first of all leukemias and lymphomas. Yet some groups use also total body irradiation in the treatment of some solid tumours of dismal prognosis--for instance in case of advanced neuroblastomas or Ewing's sarcomas. |
