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Carcinogenicity of 6-aminochrysene in mice

par Lambelin, Georges;Roba, José;Roncucci, Roméo;Parmentier, Raoul
Référence European journal of cancer, 11, 5, page (327-328,IN5-IN6,329-334)
Publication Publié, 1975

Article révisé par les pairs

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Résumé :

Long term topical skin application of 6-aminochrysene (6-AMC) to mice induced development of benign skin tumours after 3 months and of skin malignancies after 7 months. Primitive cutaneous tumours arose at the site of application and other lesions arose elsewhere on the skin and in the viscera. Gross and histopathological examination revealed that 92% of mice in the 6-AMC treated groups carried tumours, compared to 6 and 5% respectively in vehicle-treated and untreated controls. In the 6-AMC treated mice, lung tumours were observed in 71% of the animals and liver lesions in 38%. Female mice responded earlier than males. Induction of skin tumours was more rapid when 6-AMC was applied ventrally instead of dorsally. Bioavailability studies with 3H-6-AMC indicated that urinary excretion is about twice as high after skin application than after oral administration. © 1975.