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Chemistry on polymer supports. 2. Intrapolymer interaction in alkylation of CH acids [1]

par Szabo, Laszlo ;Tétényi, Péter;Pecher, Johannes
Référence Reactive Polymers, 11, C, page (47-56)
Publication Publié, 1989

Article révisé par les pairs

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Résumé :

Mono- and dialkylation of diethyl malonate and diethyl 2-butylmalonate with chloromethyl polystyrene were studied. Progress of the reaction was followed on the support by the relative absorbance of the carbonyl stretching band at 1730 cm-1 and, after pyridylation, by the relative absorbance of the pyridinium band at 1630 cm-1. Time vs. absorbance and conversion vs. absorbance relations showed that the second alkylation is predominant at high loading of the polymer (3.40 mM CH2Cl/g substrate polymer) and cannot be assumed to be negligible even at low loading (0.45 mM/g). The extent of the second alkylation increased with reaction time and cannot be eliminated completely by a high reagent : substrate ratio of 35. © 1989.