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Expert system for pharmaceutical analysis. II. Relative contribution of and rule validation for amperometric detection (oxidation mode)

par Musch, Greet;Massart, Désiré Luc
Référence Journal of chromatography, 370, C, page (1-19)
Publication Publié, 1986

Article révisé par les pairs

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Résumé :

The expert system predicted correctly whether a drug could be detected with an amperometric detector (oxidation mode) in 93% of the compounds investigated. The validation was performed for drugs possessing a low molar extinction coefficient and for pharmaceuticals containing only small amounts of drugs. For 50% of this group of drugs, the amperometric detector could be used and the sensitivity was significantly increased in comparison with UV detection. The remaining groups of drugs, i.e., for those for which neither UV detection nor the amperometric detector offered a solution, are also reported, together with some UV-inactive drugs that could be determined only by amperometric detection. © 1986.