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Hepatitis B vaccine effectiveness in the face of global HBV genotype diversity

par Cassidy, Adrian;Mossman, Sally P.;Olivieri, Antonio;De Ridder, Marc ;Leroux-Roels, Geert
Référence Expert review of vaccines, 10, 12, page (1709-1715)
Publication Publié, 2011-12

Article révisé par les pairs

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Résumé :

Recombinant hepatitis B vaccines are of the A2 genotype; one of ten known genotypes whose distribution varies globally. Reports of rare HBV infections in blood donors with an imbalance of non-A2 genotype HBV in vaccinated subjects have raised questions about the cross-protection afforded by HBV-A2 vaccines. Infections in HBV vaccinees were asymptomatic and transient, indicating that vaccination prevented clinical disease. Preclinical data demonstrate cross-reactivity and cross-protection by A2 vaccines against non-A2 HBV genotypes. Substantial improvements in HBV control have been demonstrated in countries with diverse genotype distribution that have introduced universal childhood HBV vaccination programs. Available data show that current HBV-A2 vaccines are highly effective in preventing infections and clinical disease caused by all known HBV genotypes. © 2011 Expert Reviews Ltd.