Résumé : We present a chemometric procedure for the identification of the reference standard chromatographic peak in cases where the GC-FTIR analysis of commercial standards results in the appearance of more than one peak in the GC chromatogram. The procedure has been designed for phenethylamines, which represent the class with the largest number of individual molecules on the illicit drug market, and which are abused for their stimulant and/or hallucinogenic effects. The similarity between their vapor-phase FTIR spectra was modeled using principal component analysis (PCA), and class identity was assigned on the basis of soft independent modeling of class analogy (SIMCA). Additional peaks could be assigned to impurities in the standards, but most often they were artifacts formed during the GC-FTIR analysis of thermolabile or chemically unstable compounds. The latter case is illustrated by the identification of the reference standard chromatographic peak and FTIR spectrum of the potent psychotropic amphetamine derivative N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), and by the elucidation of the chemical changes that occur in the molecule of MBDB due to thermal degradation. © 2002 Elsevier Science B.V. All rights reserved.