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Hyperplasia of "pancreatic polypeptide"-cells in the pancreas of juvenile diabetics

par Gepts, Willy ;De Mey, Jan;Pipeleers-Marichal, Miriam
Référence Diabetologia, 13, 1, page (27-34)
Publication Publié, 1977-01

Article révisé par les pairs

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Résumé :

The cellular composition of the pancreatic islets of juvenile diabetics was studied, using recently developed immunocytochemical methods. B-cells were identified only in juvenile diabetics with a disease of short duration. In chronic juvenile diabetics, the islets which are classically viewed as "atrophic", were shown to be composed of glucagon- and of somatostatin-cells. Another type of islets which commonly occurs in the pancreas of juvenile diabetics, i. e. the ribbon-like type first described by Cecil in 1911, appeared to be composed almost exclusively of "pancreatic polypeptide" (HPP)-cells. It is suggested that hyperplasia of the HPP-cells in the pancreas of juvenile diabetics results from an atypical type of islet regeneration induced by a severe and prolonged injury to the pancreatic endocrine tissue. © 1977 Springer-Verlag.