Titre :
  • Global histone deacetylase enzymatic activity is an independent prognostic marker associated with a shorter overall survival in chronic lymphocytic leukemia patients.
Auteur : Van Damme, Michaël ; Crompot, Emerence ; Meuleman, Nathalie ; Mineur, Philippe ; Dessars, Barbara ; El Housni, Hakim ; Bron, Dominique ; Lagneaux, Laurence ; Stamatopoulos, Basile
Informations sur la publication : Epigenetics, 9, 10, (page 1374-1381)
Statut de publication : Publié, 2014
Sujet CREF : Hématologie
Mots-clés : B2M, Beta-2-microglobulin
BCR, B cell receptor
CLL, Chronic lymphocytic leukemia
FCR Fludarabine-cyclophosphamide-rituximab
HDAC
HDAC, Histone deacetylase
HDACi, HDAC inhibitor
HR Hazard ratio
IgHV, Immunoglobulin heavy-chain variable-region
LDT, Lymphocyte doubling time
LPL, Lipoprotein lipase
MSC, Mesenchymal stromal cell
NF-κB, Nuclear factor κB
OS, Overall survival
SAHA, Suberoylanilide hydroxamic acid
SIRT, Sirtuin
Sirtuin
TFS, Treatment-free survival
VPA, Valproic acid
ZAP70, Zeta-chain-associated protein kinase 70
Note : SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:1559-2294 
info:doi/10.4161/15592294.2014.969628
info:pmid/25437053