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Quantitative study of liver metastases from colon cancer in rats after treatment with cyclosporine A

par Van der Elst, Josiane;De Greve, Jacques;Geerts, Frank;De Neve, Wilfried;Storme, Guy ;Willems, Glenda
Référence Journal of the National Cancer Institute, 77, 1, page (227-232)
Publication Publié, 1986

Article révisé par les pairs

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Résumé :

Liver metastases were produced in syngeneic BD IX rats by intraportal injection of colon cancer cell aggregates. The cells originated from the DHD/K12 cell line, derived from a 1,2-dimethylhydrazine (CAS: 540-73-8)-induced colon adenocarcinoma in BD IX rats. The animals received either cyclosporine A (CSA) or the excipiens alone (control) through daily gastric intubation during 6 weeks. Multiple and very large hepatic metastases were observed early in 100% of the CSA-treated rats. The mean tumor volume was approximately 2,000 times higher in the CSA-treated group than in the controls (P < .01). Survival time in the CSA-treated group was shortened (P < .01) by generalized metastatic disease. Easy production of metastasis from colon cancer in 100% of the animals and precise estimation of tumor volume may prove useful for future therapeutic studies of secondary hepatic disease.