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Electron microscopic studies of metachromatic leucodystrophy - II. Compound nature of the inclusions

par Grégoire, Anne
Référence Acta Neuropathologica, 9, 3, page (244-253)
Publication Publié, 1967-09

Article révisé par les pairs

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Résumé :

In metachromatic leucodystrophy, the glial intracytoplasmic inclusions contain a compound material with two different parts: 1. Complex lipids organized in parallel sheets, often piled up to form narrow prisms limited by a dense partition. 2. Unstructurated material which occupies all the space between the lipids, unstained by the usual electron microscopic techniques. It presents a strong affinity for PTA and becomes then very electron dense. This affinity disappears afterdigestion by hyaluronidase and remains unchanged after the action of proteases (trypsin, pronase). This gives evidence of the presence within the inclusions of an association of mucopolysaccharides and lipids. The interstitial PTA stained material represents the mucopolysaccharide moiety. © 1967 Springer-Verlag.