par Tondeur, F.;Rommelaere, Jean
Référence Biochimica et biophysica acta, N. Nucleic acids and protein synthesis, 475, 4, page (562-570)
Publication Publié, 1977-04
Article révisé par les pairs
Résumé : Incubation of Chinese hamster cells with labelled caffeine leads to transfer of radioactivity to DNA. This association occurs during the S phase of the cell cycle and involves parental as well as newly synthesised strands. The replacement of thymidine by BrdUrd prevents the incorporation radio-activity from caffeine into the DNA strands containing BrdUrd. Thymine is the only base which becomes labelled and data suggesting the participation of methyl groups of caffeine in the biosynthesis of thymine are presented. Ultraviolet irradiation increases the incorporation of radioactivity from caffeine to DNA. © 1977.