• Citer

Asymmetric synthesis of fluorinated l-tyrosine and meta-l-tyrosines

par Monclus, Michel ;Masson, Carine;Luxen, André
Référence Journal of fluorine chemistry, 70, 1, page (39-43)
Publication Publié, 1995-01

Article révisé par les pairs

• Détails
• Contenu

Résumé :

A convenient asymmetric synthesis of (2S)-2-amino-3-(2-fluoro-5-hydroxyphenyl) propanoic acid, (2S)-2-amino-3-(4-fluoro-3-hydroxyphenyl) propanoic acid and (2S)-2-amino-3-(2-fluoro-4-hydroxyphenyl) propanoic acid is described. Key steps include the synthesis of the benzyl bromides, the alkylation of the glycine enolate derivative ((S)-Boc-BMI) and the hydrolysis of the alkylated Boc-BMI. © 1995.