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Subcutaneous panniculitis-like T-cell lymphoma: Further evidence for a distinct neoplasm originating from large granular lymphocytes of T/NK phenotype

par Dargent, Jean-Louis ;Roufosse, Candice;Delville, Jean Pierre;Kentos, Alain ;Delplace, Jérôme;Kornreich, Anne ;Cochaux, Pascale ;Hilbert, Pascale ;Pradier, Olivier ;Feremans, Walter
Référence Journal of cutaneous pathology, 25, 7, page (394-400)
Publication Publié, 1998

Article révisé par les pairs

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Résumé :

We report the case of a 20 year-old caucasian woman who presented a primary subcutaneous panniculitis-like T-cell lymphoma (SPTCL) as an invasive tumor of the chest wall. Herein, the neoplastic cells were found to express a CD3+CD8+ phenotype but also displayed variably the natural killer (NK)-associated antigens CD56 and CD57 as well as granzyme B. On cytological examination, these cells showed a large granular lymphocyte (LGL)-like morphology with presence of azurophilic granules in their cytoplasm. Electron dense and membrane bound granules like those found in cytotoxic T lymphocytes (CTL) were also demonstrated by electron microscopy. Neither rearrangement of the T-cell receptor subunits nor Epstein-Barr virus (EBV) genome was observed at the molecular level. The LGL-like features of the neoplastic cells found in this case and the presence of NK-associated antigens provide additional support to the cytotoxic derivation of most SPTCL.