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Experimental designs and their recent advances in set-up, data interpretation, and analytical applications.

par Dejaegher, Bieke ;Vander Heyden, Yvan
Référence Journal of pharmaceutical and biomedical analysis, 56, 2, page (141-158)
Publication Publié, 2011

Article révisé par les pairs

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Résumé :

In this review, the set-up and data interpretation of experimental designs (screening, response surface, and mixture designs) are discussed. Advanced set-ups considered are the application of D-optimal and supersaturated designs as screening designs. Advanced data interpretation approaches discussed are an adaptation of the algorithm of Dong and the estimation of factor effects from supersaturated design results. Finally, some analytical applications in separation science, on the one hand, and formulation-, product-, or process optimization, on the other, are discussed.