par Ley, Robert 
;Willems, Glenda ;Vansteenkiste, Y.
Référence Gastroenterology, 65, 5, page (764-772)
Publication Publié, 1973
;Willems, Glenda ;Vansteenkiste, Y.Référence Gastroenterology, 65, 5, page (764-772)
Publication Publié, 1973
Article révisé par les pairs
| Résumé : | 4 successive intraperitoneal injections of 3H-thymidine were performed in rats submitted either to vagotomy and pyloroplasty, to pyloroplasty alone, or to sham operation. From 3 to 5 animals of each group were killed at intervals after these injections and the rate of appearance of labeled parietal cells in the fundic mucosa was studied autoradiographically. The percentages of labeled parietal cells observed after the 19th and the 30th day were much lower in the vagotomized animals (P <0.01) than in the control animals. This indicates that, in rats, the production of young parietal cells is decreased after vagotomy. In a control experiment, deoxyribonucleic acid synthesis and mitotic indices were compared in rats submitted to one or the other of the 3 surgical procedures by using single injections of 3H-thymidine. A slight increase in both parameters was observed in the fundic mucosa of the vagotomized animals. Thus, no decrease in mitotic activity of the fundic progenitor cells could explain the retarded parietal cell production after vagotomy. |
