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Isolement et propriétés d'une mélanine obtenue à partir de mélanogènes urinaires dans un cas de maladie de dubinjohnson

par Sonnet, Jean;Steichen, Marc ;Brisbois, P.
Référence Clinica chimica acta, 24, 3, page (325-333)
Publication Publié, 1969-06

Article révisé par les pairs

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Résumé :

The authors report on the clinical history of a patient having the features of the chronic idiopathic jaundice of Dubin-Johnson disease, in whom a dark pigment was recovered from the urines. This pigment had several properties (solubility, U.V. and I.R. absorption spectra, electrophoretic mobility in agar gel), quite similar to those of melanin obtained from various human materials (hair, choroid, urine from a melanoma patient), or synthesized from adrenochrome. These data suggest strongly that the pigment under study is a true melanin resulting from the oxidation of unidentified precursors or melanogens excreted by the patient. © 1969.