par Sundler, Frank;Christophe, Jean 
;Robberecht, Patrick ;Yanaihara, Noboru;Yanaihara, Chizuko;Grunditz, Torsten;Håkanson, Rolf
Référence Regulatory peptides, 20, 1, page (83-89)
Publication Publié, 1988
;Robberecht, Patrick ;Yanaihara, Noboru;Yanaihara, Chizuko;Grunditz, Torsten;Håkanson, RolfRéférence Regulatory peptides, 20, 1, page (83-89)
Publication Publié, 1988
Article révisé par les pairs
| Résumé : | Helodermin is a VIP/secretin-like 35-amino acid peptide originally isolated from the venom of the lizard Gila monster. Recently, helodermin-immunoreactive material was demonstrated in mammalian salivary glands, brain and gut. In the present study 8 human medullary thyroid carcinomas as well as 4 normal thyroid glands were examined immunocytochemically for the presence of helodermin using an antiserum raised against helodermin-(5-35) that does not cross-react with VIP or secretin. Cells displaying helodermin-like immunoreactivity were found in all tumours examined except one. On the whole the helodermin-immunoreactive cells had the same distribution as those storing calcitonin, suggesting coexistence of the two peptides in most of the tumour cells. Also normal human C-cells displayed helodermin immunoreactivity. The results suggest that a peptide chemically related to helodermin is a constituent of human medullary thyroid carcinoma cells as well as of normal C-cells. © 1988. |
