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Steroid metabolism in vitro by gonadal tissue from a true hermaphrodite

par Vancrombreucq, T.;Govaerts, M.;Preumont, Pierre ;Schwers, Jean
Référence Hormone research, 10, 6, page (303-309)
Publication Publié, 1979

Article révisé par les pairs

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Résumé :

The case of a true hermaphrodite, with a normal ovary and an ovotestis is presented. The ovotestis was removed and incubated in vitro with tritiated steroids (testosterone, dehydroepiandrosterone, pregnenolone and 17α-hydroxyprogesterone). Labeled metabolites were isolated and identified. Based upon these findings, a pathway of steroid biogenesis in this abnormal gonadal tissue is suggested. The ovotestis studied did not contain all the enzymes involved in ovarian steroidogenesis: 3β-hydroxysteroid dehydrogenase, isomerase, 17-20 desmolase and 17β-hydroxysteroid dehydrogenase were present, but other important enzymes, such as 16 and 17-hydroxylases, and aromatizing enzyme systems, were deficient or absent.