par Karlin, Sophie ;Stavric, Vl;Smuk, Magdolna ;Sugar, Judith;Schwers, Jean
Référence The Journal of clinical endocrinology and metabolism, 49, 4, page (588-593)
Publication Publié, 1979
Article révisé par les pairs
Résumé : Renal clearance of estriol (E 3), E 3-3-sulfate (E 3S), E 3-16-glucuronide (E 316G), E 3-3-glucuronide (E 33G), and E 3-3-sulfate-16-glucuronide (E 3SG) has been measured in 13 normal and 17 abnormal pregnancies between the 33rd and 40th week of gestation. The methodology involved a chromatographic separation on a celite column in the presence of tritiated tracers, enzymic hydrolysis of the conjugates, and measurement of the E 3 moiety by a specific RIA. Preeclampsia (eight patients) was characterized by a significant decrease of renal clearance of all conjugates except E 33G. In contrast to that pattern, a patient with cholestatic icterus had normal clearances except for E 33G, which was reduced to less than 15% of its normal mean value. Administration of ampicillin to a pregnant woman induced an important decrease of all E 3 clearances, especially for E 33G which decreased to nearly 1% of its initial value; normal clearances were resumed within a week after the end of the treatment. In a small number of complicated pregnancies, E 3 clearances were normal. A significant correlation between the renal clearance of E 316G and that of urea and creatinine has been demonstrated.