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Easy production and early detection of liver metastases of colon cancer in rats

par Qin, Yunfeng;Koen, D.;Willems, Glenda
Référence Surgical research communications, 9, 2, page (99-105)
Publication Publié, 1990

Article révisé par les pairs

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Résumé :

A reliable model with liver metastases of colon cancer was established in this study by injecting DHD/K12 colon adenocarcinoma cells into the spleen of syngeneic BDIX rats treated with cyclosporine A. All the rats developed visible hepatic metastases at 4-6 weeks after tumor inoculation with an average of 16 metastatic foci in each liver. The mean diameter of the tumor nodules was 2.7 mm. Such a model carrying a 100% reproducibility may be a valuable tool for the study of tumor growth in the liver. In addition, the possibility of using CT scanning to detect small liver metastatic tumors was investigated in this study. Our results indicated that CT had an accuracy rate of 75% in the detection of liver metastases in rats.