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Arginine and cysteine residues in the ligand binding site of alpha 2- adrenergic receptors

par Mattens, E.;Vauguelin, G.;Bottari, Serge P. ;Vokaer, Alain Patrick
Référence Life sciences, 36, 4, page (355-362)
Publication Publié, 1985-01

Article révisé par les pairs

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Résumé :

α2- Adrenergic receptors were identified in calf brain, human platelet and human uterus membranes by [3H]-rauwolscine binding.The reagents phenylglyoxal (selective for guanidino groups), p- hydroxy mercuribenzoate and N-ethylmaleimide (selective for sulfhydryl groups) caused a time- and dose- dependent decrease in the number of receptor sites. α2-Adrenergic agonists and antagonists mediated efficient protection of the receptors against these reagents. These data suggest that essential arginine and cysteine residues are present at or near the α2-adrenergic binding site. © 1985.