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Linkage of mood disorders with D2, D3 and TH genes: A multicenter study

par Serretti, Alessandro;Macciardi, Fabìo;Cusin, Cristina;Lattuada, Enrico;Smeraldi, Enrico;Souery, Daniel ;Lipp, Olivier;Mahieu, Brigitte;Mendlewicz, Julien ;Van Broeckhoven, Christine;Raeymaekers, Peter;Verheyen, Geert R.;Blackwood, Douglas Hr;Muir, Walter;Aschauer, Harald Nikolaus;Heiden, Angela A.M.;Ackenheil, Manfred;Fuchshuber, Sybille;Kaneva, Radka Petrova;Jablensky, Assen;Papadimitriou, George;Dikeos, Dimitris;Stefanis, Costas N
Référence Journal of affective disorders, 58, 1, page (51-61)
Publication Publié, 2000-04

Article révisé par les pairs

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Résumé :

Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.