par Stock, Christiane;Launay, Jean François;Grenier, Jacques J.F.;Bauduin, Henri
Référence Biochemical and biophysical research communications, 76, 2, page (217-223)
Publication Publié, 1977-05
Article révisé par les pairs
Résumé : The effects of VB4 4 VB = Vinblastine sulphate. It was a generous gift from Eli Lilly (St-Cloud, France). on both structure and function of the pancreatic acinar cell have been examined in vitro. VB potentiates the secretagogue effect of DbcAMP5 5 DbcAMP = N6-2′-0-Dibutyryl-adenosine 3′,5′-monophosphate, cyclic. but fails to affect the spontaneous release of enzymes. This potentiation is parallel to the disappearance of cellular microtubules and depends on the dose and the time of exposure to VB. The potentiation is energy dependent; it is more obvious in calcium containing medium than in absence of calcium. A damaging effect of VB an acinar cells is ruled out. These findings suggest the participation of microtubules in the secretory cycle of the pancreatic acinar cell. © 1977.