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Vaccination of newborns of HBsAg-positive carrier mothers with a recombinant DNA hepatitis B vaccine

par Cadranel, Samy ;Zeghlache, S.;Fernandez, Socorro;Safary, Assad;Andre, Francis
Référence Postgraduate medical journal, 63, SUPPL. 2, page (159-160)
Publication Publié, 1987

Article révisé par les pairs

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Résumé :

Thirty neonates born to HBsAg-positive mothers were vaccinated with a 20 μg dose of the SmithKline Biologicals recombinant DNA yeast-derived vaccine within 24 hours after birth, with similar inoculations repeated 1 and 2 months later. Preliminary results indicate that the recombinant vaccine was well tolerated and immunogenic. A 100% seroconversion rate was achieved 4 months after the vaccine dose and the anti-HBs geometric mean titres progressively rose from 14 to 31, 279 and 361 IU/l at months 1, 2, 4, and 6, respectively. Although a longer period of observation and comparison with a historical control group are needed to evaluate its protective efficacy in this high-risk population, the fact that no vaccinated newborns have been infected is encouraging.