Article révisé par les pairs
Résumé : The mechanism of mutagenicity of chloroethylene oxide (CEO), an ultimate carcinogenic metabolite of vinyl chloride, was investigated in 3 Escherichia coli strains (E. coli "multitest"). In this system, the mutagenicity of CEO was found to be mainly SOS-independent. CEO did not induce recombinational events at a detection level of about 10-2 recombinants/survivor. Our results indicate that CEO- (or vinyl chloride-) induced bacterial mutagenesis arise mainly from miscoding DNA adducts. © 1985.