par Anderson, Stewart;Vanderhaeghen, Pierre
Référence Current opinion in neurobiology, 27, page (151-157)
Publication Publié, 2014
Article révisé par les pairs
Résumé : The cerebral cortex contains dozens of neuronal subtypes grouped in specific layers and areas. Recent studies have revealed how embryonic and induced pluripotent stem cells (PSC) can differentiate into a wide diversity of cortical neurons in vitro, while recapitulating many of the temporal and spatial features that characterize corticogenesis. PSC-derived neurons can integrate into the brain following in vivo transplantation and display patterns of morphology and connectivity specific of cortical neurons. PSC-corticogenesis thus emerges as a robust model that provides new ways to link cortical development, evolution, and disease. © 2014.