par Leemans, Charles René;Tijink, Bernard B.M.;Langendijk, Johannes J.A.;Andry, Guy ;Hamoir, Marc;Lefebvre, Jean-Louis
Référence European journal of surgical oncology, 39, 9, page (1013-1018)
Publication Publié, 2013-09
Article révisé par les pairs
Résumé : Background The Head and Neck Cancer Group (HNCG) of the EORTC conducted a quality assurance program in the EORTC 24954 trial on larynx preservation. In this multicentre study, patients with resectable advanced squamous cell carcinoma of the larynx or hypopharynx were randomly assigned for treatment with sequential or alternating chemoradiation. The need for a quality assurance program is the evaluation and prevention of differences in treatments between centres in this multidisciplinary study. Method The surgical subcommittee of the HNCG prepared a questionnaire, and clinical records of all patients were verified during audits of independent teams. Data relating institutional practices were collected during a face to face interview with members of the local team. Results 271 clinical records from the nine main contributing centres were reviewed. The main difference between centres was the time interval between first consultation and treatment initiation, with a mean of 45 days. On the pathology report the nodal involvement was described by level in 36% of the cases according to the American Academy of Otolaryngology - Head and Neck Surgery classification. Extranodal spread was not always described in neck dissection specimens. Conclusion The EORTC 24954 trial on larynx preservation was the first prospective trial with a quality assurance program in head and neck surgical oncology. The analysis shows similarities in practices, but also points out some important differences between centres. Operation reports were fairly complete, but uniformity in pathology reports should be improved. © 2013 Elsevier Ltd. All rights reserved.

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