Résumé : The aim of the study was to evaluate the consequences of the administration of paracetamol on the mean arterial pressure (MAP) of patients hospitalized in an intensive care unit, as well as the influence of the route of administration (oral vs. IV). This is an observational, prospective, and single center study that has been carried out in the medical and surgical intensive care unit (ICU) of the Centre Hospitalier de Jolimont, Haine Saint-Paul (Belgium). A cohort of 107 consecutive patients was collated over a period of three months. A group of 75 patients (group 1) received an unique dose of 1g of paracetamol intravenously and was compared to a group of 32 patients (group 2) who received the same dose orally (effervescent tablets). MAP was recorded either non-invasively (cuff), or with invasive means (arterial line), before (T0) and 15, 30, 45, 60, 90, and 120 min after administration of the drug. In both groups, the administration of paracetamol resulted in a drop of MAP of 10 to 20% in 30 patients (28% of the cohort), 20% to 40% in 23 patients (21%) and over 40% in 4 patients (3.7%). Six patients (5%) had to be treated by fluid replacement or vasopressors during the observation period. No significant difference in regard to the magnitude of the fall of MAP was noted between the two groups. The kinetics of the fall in blood pressure was essentially identical in both groups with a decrease of 5-6% occurring already at 30 min. Beyond 30 min, the MAP stabilized in group 1 with the blood pressure nadir observed at 30 min, whereas it tended to further decrease in group 2 with a delayed blood pressure nadir (-10% vs. T0) in the ninetieth minute. We believe that this observation is important as it draws the attention on the need for a strict hemodynamic monitoring in the many patients hospitalized in ICU and receiving paracetamol and on the anticipation it implies about the vigilance of the medical staff to quickly address these hemodynamic changes.