par Bieliavsky, Nicolas 
Référence Experimental cell research, 32, 2, page (342-353)
Publication Publié, 1963-11
Référence Experimental cell research, 32, 2, page (342-353)
Publication Publié, 1963-11
Article révisé par les pairs
| Résumé : | Mitomycin treatment of pleurodele embryos at the morula stage blocks the development. After cleavage the effect of mitomycin is considerably decreased; it has no effect on embryos treated during or after the gastrula stage: this decline in mitomycin sensitivity could be due, partially at least, to the inpermeability of the cortex. Cytochemical studies of the effects of mitomycin on the dissociated cells of young morulae show that a degradation of the chromosome structure of mitotic cells is provoked. In interphase nuclei abnormalities appear: the incorporation of thymidine into DNA is stimulated, and the interphase period is prolonged and variable. During the extended interphase, DNA seems to accumulate in the nucleus. Following interphase, some nuclei enter into a mitosis which is, in general, abortive, while others lose their DNA without entering into prophase. © 1963. |
