par Chantrenne, Hubert 
Référence Biochimica et biophysica acta, 2, C, page (286-293)
Publication Publié, 1948
Référence Biochimica et biophysica acta, 2, C, page (286-293)
Publication Publié, 1948
Article révisé par les pairs
| Résumé : | Phenyl benzoylphosphoric acid has been synthesized; its crystalline sodium and silver salts have been isolated. Phenyl benzoylphosphate is very stable at 37° in aqueous solution of pH 7.4. It reacts readily at 37° with glycine in aqueous solution (pH 7.4) forming hippuric acid. A peptide linkage thus spontaneously forms under "physiological" conditions of pH and temperature, in a reaction involving an aminoacid and an acylphosphate derivative. Phenyl benzoylphosphate also reacts with ammonia and, much more slowly, with aromatic amines. Dibenzoylphosphate and phenyl benzoylphosphate are much less readily hydrolysed than monobenzoylphosphate in presence of tissue extracts containing acylphosphatase. These results are discussed with special reference to their possible significance for the understanding of the mechanism of peptide linkage formation. © 1948. |
