par Thonnart, Nadine;Letist, Danièle 
;Reuse, Joannes
Référence Archives internationales de pharmacodynamie et de thérapie, 208, 2, page (369-372)
Publication Publié, 1974
;Reuse, Joannes Référence Archives internationales de pharmacodynamie et de thérapie, 208, 2, page (369-372)
Publication Publié, 1974
Article révisé par les pairs
| Résumé : | After intraperitoneal injection of clocoumarol (DB 112), a new antivitamin K, into female rats, plasma levels were determined spectrophotometrically and followed for 24 hr. The kinetics were biphasic. After administration of proadifen, the second, slower phase was prolonged. On the other hand, proadifen potentiated the anticoagulant effect of clocoumarol. These results are compatible with the known inhibitory action of proadifen on biotransformation. |
