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Transmembrane effects of lectins. I. Effects of wheat germ agglutinin and soybean agglutinin on furrow formation and cortical wound healing in Xenopus laevis eggs

par Tencer, Renée
Référence Experimental cell research, 116, 2, page (253-260)
Publication Publié, 1978-10

Article révisé par les pairs

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Résumé :

Studies on the binding of FITC-WGA and FITC-SBA to normal and cytochalasin (CB)-treated Xenopus eggs have demonstrated the presence of lectin receptors all over the egg surface; there are aggregates of receptors in the region where microvilli are numerous and microfilaments well organized. Addition of WGA or SBA to the incubation medium provokes inhibition of furrow formation provided that the lectins are added before the streak stage, or arrest of contraction when added during furrow formation. This arrest of contraction is followed by furrow regression. The lectins also affect wound healing. All these effects may be explained by an inhibition of membrane proteins movement and an alteration of the relations between the surface and the cytoskeleton. © 1978.