par Van Gansbeke, Bernard ;Schoutens, André ;Timmermans, Jacques ;Moes, André Jules
Référence International Journal of Radiation Applications and Instrumentation., 18, 7, page (711-713,715-718)
Publication Publié, 1991
Article révisé par les pairs
Résumé : A triple nuclide scintigraphic technique is presented for the precise and lasting intragastric monitoring in man of two concurrently ingested hydrophilic matrix pharmaceutical forms. After in vitro testing of various labels, ion exchange resin-coupled 201Tl- and 111In-oxinate were selected for their release characteristics. 99mTc-pertechnetate oral solution was used to selectively delineate the stomach. This technique was validated on healthy volunteers. It allowed measurement of the effects on gastric residence time of galenic parameters (size, density of matrices), as well as of physiological parameters such as subject posture. © 1991.