Titre :
  • Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of NF-kB and endoplasmic reticulum stress
Auteur : Kharroubi, Ilham ; Ladrière, Laurence ; Cardozo, Alessandra K ; Dogusan, Zeynep ; Cnop, Miriam ; Eizirik, Decio L.
Informations sur la publication : Endocrinology, 145, (page 5087-5096)
Statut de publication : Publié, 2004
Sujet CREF : Médecine clinique [biologie clinique]
Mots-clés MeSH : Animals
Apoptosis -- drug effects
Apoptosis -- physiology
Carcinogens -- pharmacology
Cell Line, Tumor
Cytokines -- pharmacology
Drug Synergism
Endoplasmic Reticulum -- metabolism
Fatty Acids, Nonesterified -- toxicity
Flow Cytometry
Insulinoma
Interferon-gamma -- pharmacology
Interleukin-1 -- pharmacology
Islets of Langerhans -- cytology
Islets of Langerhans -- drug effects
Islets of Langerhans -- metabolism
Male
NF-kappa B -- metabolism
Oleic Acid -- toxicity
Palmitates -- toxicity
Pancreatic Neoplasms
Rats
Rats, Wistar
Thapsigargin -- pharmacology
Tumor Necrosis Factor-alpha -- pharmacology
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0013-7227 
info:doi/10.1210/en.2004-0478
info:pii/en.2004-0478
info:pmid/15297438
cm-0040