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Results of a E.O.R.T.C. randomized trial of cyclophosphamide and radiotherapy in inoperable lung cancer: Prognostic factors and treatment results

par Byar, David D.P.;Kenis, Yvon ;Van Andel, Jaap J.G.;de Jong, Maria C J W M.;Laval, P.;Marion, Lester;Couette, Jean Etienne;Longueville, Jacques
Référence European journal of cancer, 14, 9, page (919-930)
Publication Publié, 1978-09

Article révisé par les pairs

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Résumé :

A randomized cooperative clinical trial has been conducted in inoperable carcinoma of the lung. One hundred and eighty-seven patients under age 72 of both sexes of all cell types were admitted provided they had had no previous surgery, chemotherapy or radiotherapy with the exception that patients having received less than 2g of cyclophosphamide or less than 2 weeks of chemotherapy of any kind could be included. Treatment was assigned by randomization, stratified by institution and cell type, to one of the following treatments: (1) continuous radiotherapy (6000 rad at the rate of 1000 rad per week), (2) split-course radiotherapy (3 series of 2000 rad each administered in three 2-week periods separated by 8-week intervals), (3) continuous radiotherapy plus cyclophosphamide, (4) split-course radiotherapy plus cyclophosphamide. Cyclophosphamide was given at the dose of 20 mg/kg i.v. or i.m. every 15 days starting 15 days after the completion of continuous radiotherapy or 15 days after the first course of radiotherapy for those receiving the split-dose schedule. No statistically significant differences in survival were seen between treatment groups. © 1978.