par Brecx, Valerie;Misicka, Aleksandra;Verheyden, Patricia;Tourwe, Dirk 
;Van Binst, Georges
Référence Letters in Peptide Science, 2, 3-4, page (165-168)
Publication Publié, 1995-11
;Van Binst, Georges Référence Letters in Peptide Science, 2, 3-4, page (165-168)
Publication Publié, 1995-11
Article révisé par les pairs
| Résumé : | A new cis-peptide bond mimetic, α-benzyl-o-aminomethylphenylacetic acid, was synthesized and incorporated in a homodetic somatostatin analogue. Biological binding tests and 2D NMR conformational analysis indicate that the configuration of the bridge-unit asymmetric center and the orientation of the benzyl side chain play a key role in the biological activity of this type of somatostatin analogues. © 1995 ESCOM Science Publishers B.V. |
