Article révisé par les pairs
Résumé : Objective: Medical management of primary hyperparathyroidism (PHPT) is important in patients for whom surgery is inappropriate. We aimed to describe clinical profiles of adults with PHPT receiving cinacalcet. Design: Descriptive, prospective, observational study in hospital and specialist care centres. Methods: For patients with PHPT aged 23-92 years starting cinacalcet for the first time, information was collected on dosing pattern, biochemistry and adverse drug reactions (ADRs). Initial cinacalcet dosage and subsequent dose changes were at the investigator's discretion. Results: Of 303 evaluable patients with pHTP, 134 (44%) had symptoms at diagnosis (mostly bone pain [58] or renal stones [50]). Mean albumin-corrected serum calcium (ACSC) at baseline was 11.4 mg/dL (2.9 mmol/L). Reasons for prescribing cinacalcet included: surgery deemed inappropriate (35%), patient declined surgery (28%), and surgery failed or contraindicated (22%). Mean cinacalcet dose was 43.9 (SD, 15.8) mg/day at treatment start and 51.3 (31.8) mg/day at Month 12; 219 (72%) completed 12 months' treatment. The main reason for cinacalcet discontinuation was parathyroidectomy (40; 13%). At 3, 6 and 12 months from the start of treatment, 63%, 69% and 71% of patients, respectively, had an ACSC of ≤10.3 mg/dL versus 9.9% at baseline. Reductions from baseline in ACSC of ≥1 mg/dL were seen in 56%, 63% and 60% of patients, respectively. ADRs were reported in 81 patients (27%), most commonly nausea. 7.6% of patients discontinued cinacalcet due to ADRs. Conclusions: Calcium reductions of ≥1 mg/dL were observed in 60% of patients 12 months after initiating cinacalcet, without notable safety concerns.

Documents en relation

DI-fusion