Interferon regulatory factor 3 in adaptive immune responses.

Ysebrant De Lendonck, Laure; Martinet, Valérie; Goriely, Stanislas

doi:doi/10.1007/s00018-014-1653-9

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Interferon regulatory factor 3 in adaptive immune responses.

par Ysebrant De Lendonck, Laure

;Martinet, Valérie

;Goriely, Stanislas

Référence Cellular and molecular life sciences
Publication Publié, 2014-05

Article révisé par les pairs

Résumé :

Interferon regulatory factor (IRF) 3 plays a key role in innate responses against viruses. Indeed, activation of this transcription factor triggers the expression of type I interferons and downstream interferon-stimulated genes in infected cells. Recent evidences indicate that this pathway also modulates adaptive immune responses. This review focuses on the different mechanisms that are implicated in this process. We discuss the role of IRF3 within antigen-presenting cells and T lymphocytes in the polarization of the cellular immune response and its implication in the pathogenesis of immune disorders.

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