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Comparative study of the CCF-like pattern recognition protein in different Lumbricid species

par Šilerová, Marcela;Procházková, Petra;Josková, Radka;Josens, Guy ;Beschin, Alain ;De Baetselier, Patrick;Bilej, Martin
Référence Developmental and comparative immunology, 30, 9, page (765-771)
Publication Publié, 2006

Article révisé par les pairs

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Résumé :

Coelomic fluid of the Lumbricid Eisenia fetida contains a 42-kDa pattern recognition protein named coelomic cytolytic factor (CCF) that binds microbial cell wall components and triggers the activation of the prophenoloxidase cascade, an important invertebrate defense pathway. Here we report on the sequence characterization of CCF-like molecules of other Lumbricids: Aporrectodea caliginosa, Aporrectodea icterica, Aporrectodea longa, Aporrectodea rosea, Dendrobaena veneta, Lumbricus rubellus and Lumbricus terrestris, and show that CCF from E. fetida has a broader saccharide-binding specificity, being the only one recognizing N,N′-diacetylchitobiose. We suggest that the broad recognition repertoire of E. fetida CCF reflects a particular microbial environment this species lives in. © 2005 Elsevier Ltd. All rights reserved.