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Differential diagnosis of adnexal masses: Sequential use of the risk of malignancy index and HistoScanning, a novel computer-aided diagnostic tool

par Vaes, Evelien;Manchanda, Ranjit;Autier, Philippe;Nir, Rina;Nir, Dror;Bleiberg, Harry ;Robert, Annie ;Menon, Usha
Référence Ultrasound in obstetrics & gynecology, 39, 1, page (91-98)
Publication Publié, 2012-01

Article révisé par les pairs

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Résumé :

Objective: To assess the value of ovarian Histo-Scanning™, a novel computerized technique for interpreting ultrasound data, in combination with the risk of malignancy index (RMI) in improving triage for women with adnexal masses. Methods: RMI indices were assessed in 199 women enrolled in a prospective study to investigate the use of HistoScanning. Ultrasound scores were obtained by blinded analysis of archived images. The following sequential test was developed: HistoScanning was modeled as a second-line test for RMI between a lower cut-off and an upper cut-off. The optimal combination of these cut-offs that together maximized the Youden index (Sensitivity + Specificity - 1) was determined. Results: Using RMI at the standard cut-off value of 250 resulted in a sensitivity of 74% and a specificity of 86%. When RMI was combined with HistoScanning, the highest accuracy was achieved by using HistoScanning as a sequential second-line test for patients with RMI values between 105 and 2100. At these cut-off values, sequential use of RMI and HistoScanning resulted in mean sensitivity and specificity estimates of 88% and 95%, respectively. Conclusions: Our data suggest that HistoScanning may have the potential to improve the diagnostic accuracy of RMI, which could result in better triage for women with adnexal masses. Further prospective validation is warranted. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.