• Citer

Selective expression of a neuromodulatory cytokine (IL-2) in specific brainstem neurovegetative centers: A possible final common neuro-molecular pathway in dying patients

par Kadhim, Hazim ;Deltenre, Paul ;Segers, Valérie ;Sébire, Guillaume
Référence Medical hypotheses, 78, 6, page (793-795)
Publication Publié, 2012-06

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

Cytokines interact with neurotransmitters and modify neuronal and neuroimmune functions. Intense in situ neuronal IL-2 immunoreactivity was detected in vital human brainstem neuronal centers which are principally implicated in cardio-respiratory control mechanisms. These observations were made in critically-ill aging adult as well as in young infant patients dying from various clinico-pathological conditions. We suggested that this in situ cytokine over-expression might tip a delicate balance in molecular interactions in those vital neuro-vegetative centers, causing disturbed homeostatic control of cardio-respiratory functions and impaired arousal responses; we further hypothesized that this IL-2-induced neuro-molecular disequilibrium in the brainstem microenvironment might thus be part of a final common pathway leading to death. © 2012 Elsevier Ltd.